Nuclear receptors PPARβ/δ and PPARα direct distinct metabolic regulatory programs in the mouse heart

In the diabetic heart, chronic activation of the PPARα pathway drives excessive fatty acid (FA) oxidation, lipid accumulation, reduced glucose utilization, and cardiomyopathy. The related nuclear receptor, PPARβ/δ, is also highly expressed in the heart, yet its function has not been fully delineated...

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Bibliografiset tiedot
Päätekijät: Burkart, Eileen M., Sambandam, Nandakumar, Han, Xianlin, Gross, Richard W., Courtois, Michael, Gierasch, Carolyn M., Shoghi, Kooresh, Welch, Michael J., Kelly, Daniel P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2007
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2082147/
https://ncbi.nlm.nih.gov/pubmed/18037994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32578
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