Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice

Transgenic expression of the abnormal products of acute myeloid leukemia–associated (AML-associated) primary chromosomal translocations in hematopoietic stem/progenitor cells initiates leukemogenesis in mice, yet additional mutations are needed for leukemia development. We report here aberrant expre...

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Главные авторы: Shing, Danielle C., Trubia, Maurizio, Marchesi, Francesco, Radaelli, Enrico, Belloni, Elena, Tapinassi, Cinzia, Scanziani, Eugenio, Mecucci, Cristina, Crescenzi, Barbara, Lahortiga, Idoya, Odero, Maria D., Zardo, Giuseppe, Gruszka, Alicja, Minucci, Saverio, Di Fiore, Pier Paolo, Pelicci, Pier Giuseppe
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2007
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2082144/
https://ncbi.nlm.nih.gov/pubmed/18037989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32390
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