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Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice
Transgenic expression of the abnormal products of acute myeloid leukemia–associated (AML-associated) primary chromosomal translocations in hematopoietic stem/progenitor cells initiates leukemogenesis in mice, yet additional mutations are needed for leukemia development. We report here aberrant expre...
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| Главные авторы: | , , , , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2082144/ https://ncbi.nlm.nih.gov/pubmed/18037989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32390 |
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