Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice

Transgenic expression of the abnormal products of acute myeloid leukemia–associated (AML-associated) primary chromosomal translocations in hematopoietic stem/progenitor cells initiates leukemogenesis in mice, yet additional mutations are needed for leukemia development. We report here aberrant expre...

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Detalhes bibliográficos
Main Authors: Shing, Danielle C., Trubia, Maurizio, Marchesi, Francesco, Radaelli, Enrico, Belloni, Elena, Tapinassi, Cinzia, Scanziani, Eugenio, Mecucci, Cristina, Crescenzi, Barbara, Lahortiga, Idoya, Odero, Maria D., Zardo, Giuseppe, Gruszka, Alicja, Minucci, Saverio, Di Fiore, Pier Paolo, Pelicci, Pier Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2082144/
https://ncbi.nlm.nih.gov/pubmed/18037989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32390
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