A Comparative Immunogenicity Study of HIV-1 Virus-Like Particles Bearing Various Forms of Envelope Proteins, Particles Bearing no Envelope and soluble monomeric gp120

To assess the potential of native Envelope glycoprotein (Env) trimers as neutralizing antibody vaccines, we immunized guinea pigs with three types of VLPs and soluble gp120. Particles included “SOS-VLPs” (bearing disulfide-shackled functional trimers), “UNC-VLPs” (bearing uncleaved nonfunctional Env...

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Bibliografiske detaljer
Main Authors: Crooks, Emma T., Moore, Penny L., Franti, Michael, Cayanan, Charmagne S., Zhu, Ping, Jiang, Pengfei, de Vries, Robbert P., Wiley, Cheryl, Zharkikh, Irina, Schülke, Norbert, Roux, Kenneth H., Montefiori, David C., Burton, Dennis R., Binley, James M.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2080857/
https://ncbi.nlm.nih.gov/pubmed/17580087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2007.04.033
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