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Malt1 ubiquitination triggers NF-κB signaling upon T-cell activation
Triggering of antigen receptors on lymphocytes is critical for initiating adaptive immune response against pathogens. T-cell receptor (TCR) engagement induces the formation of the Carma1–Bcl10–Malt1 (CBM) complex that is essential for activation of the IκB kinase (IKK)/NF-κB pathway. However, the mo...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2080808/ https://ncbi.nlm.nih.gov/pubmed/17948050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601897 |
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