Alternately spliced WT1 antisense transcripts interact with WT1 sense RNA and show epigenetic and splicing defects in cancer

Many mammalian genes contain overlapping antisense RNAs, but the functions and mechanisms of action of these transcripts are mostly unknown. WT1 is a well-characterized developmental gene that is mutated in Wilms’ tumor (WT) and acute myeloid leukaemia (AML) and has an antisense transcript (WT1-AS),...

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Main Authors: Dallosso, Anthony R., Hancock, Anne L., Malik, Sally, Salpekar, Ashreena, King-Underwood, Linda, Pritchard-Jones, Kathy, Peters, Jo, Moorwood, Kim, Ward, Andrew, Malik, Karim T.A., Brown, Keith W.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2080606/
https://ncbi.nlm.nih.gov/pubmed/17940140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.562907
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