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A dynamic bulge in the U6 RNA internal stem–loop functions in spliceosome assembly and activation
The highly conserved internal stem–loop (ISL) of U6 spliceosomal RNA is unwound for U4/U6 complex formation during spliceosome assembly and reformed upon U4 release during spliceosome activation. The U6 ISL is structurally similar to Domain 5 of group II self-splicing introns, and contains a dynamic...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2080595/ https://ncbi.nlm.nih.gov/pubmed/17925343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.699907 |
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