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Recombinant adeno-associated virus vectors induce functionally impaired transgene product–specific CD8(+) T cells in mice
Recombinant adeno-associated virus (rAAV) vectors were used in human trials as carriers of vaccines for HIV-1 after encouraging preclinical results. However, the clinical trials yielded disappointing results. Here we demonstrated that in mice, rAAV vectors expressing the gene encoding HIV-1 gag stim...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2078325/ https://ncbi.nlm.nih.gov/pubmed/18008010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33138 |
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