MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts

The interaction between osteoclasts (OCs) and multiple myeloma (MM) cells plays a key role in the pathogenesis of MM-related osteolytic bone disease (OBD). MM cells promote OC formation and, in turn, OCs enhance MM cell proliferation. Chemokines are mediators of MM effects on bone and vice versa; in...

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主要な著者: Vallet, Sonia, Raje, Noopur, Ishitsuka, Kenji, Hideshima, Teru, Podar, Klaus, Chhetri, Shweta, Pozzi, Samantha, Breitkreutz, Iris, Kiziltepe, Tanyel, Yasui, Hiroshi, Ocio, Enrique M., Shiraishi, Norihiko, Jin, Janice, Okawa, Yutaka, Ikeda, Hiroshi, Mukherjee, Siddhartha, Vaghela, Nileshwari, Cirstea, Diana, Ladetto, Marco, Boccadoro, Mario, Anderson, Kenneth C.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2007
主題:
Neoplasia
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2077320/
https://ncbi.nlm.nih.gov/pubmed/17715391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-093294
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