Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake

Hypothalamic fatty acid metabolism has recently been implicated in the controls of food intake and energy homeostasis. We report that intracerebroventricular (ICV) injection of leptin, concomitant with inhibiting AMP-activated kinase (AMPK), activates acetyl-CoA carboxylase (ACC), the key regulatory...

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Hlavní autoři: Gao, Su, Kinzig, Kimberly P., Aja, Susan, Scott, Karen A., Keung, Wendy, Kelly, Sandra, Strynadka, Ken, Chohnan, Shigeru, Smith, Wanli W., Tamashiro, Kellie L. K., Ladenheim, Ellen E., Ronnett, Gabriele V., Tu, Yajun, Birnbaum, Morris J., Lopaschuk, Gary D., Moran, Timothy H.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2077261/
https://ncbi.nlm.nih.gov/pubmed/17956983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708385104
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