Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake

Hypothalamic fatty acid metabolism has recently been implicated in the controls of food intake and energy homeostasis. We report that intracerebroventricular (ICV) injection of leptin, concomitant with inhibiting AMP-activated kinase (AMPK), activates acetyl-CoA carboxylase (ACC), the key regulatory...

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Detalhes bibliográficos
Main Authors: Gao, Su, Kinzig, Kimberly P., Aja, Susan, Scott, Karen A., Keung, Wendy, Kelly, Sandra, Strynadka, Ken, Chohnan, Shigeru, Smith, Wanli W., Tamashiro, Kellie L. K., Ladenheim, Ellen E., Ronnett, Gabriele V., Tu, Yajun, Birnbaum, Morris J., Lopaschuk, Gary D., Moran, Timothy H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2077261/
https://ncbi.nlm.nih.gov/pubmed/17956983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708385104
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