Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake

Hypothalamic fatty acid metabolism has recently been implicated in the controls of food intake and energy homeostasis. We report that intracerebroventricular (ICV) injection of leptin, concomitant with inhibiting AMP-activated kinase (AMPK), activates acetyl-CoA carboxylase (ACC), the key regulatory...

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Autori principali: Gao, Su, Kinzig, Kimberly P., Aja, Susan, Scott, Karen A., Keung, Wendy, Kelly, Sandra, Strynadka, Ken, Chohnan, Shigeru, Smith, Wanli W., Tamashiro, Kellie L. K., Ladenheim, Ellen E., Ronnett, Gabriele V., Tu, Yajun, Birnbaum, Morris J., Lopaschuk, Gary D., Moran, Timothy H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2077261/
https://ncbi.nlm.nih.gov/pubmed/17956983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708385104
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