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Identifying the subproteome of kinetically stable proteins via diagonal 2D SDS/PAGE

Most proteins are in equilibrium with partially and globally unfolded conformations. In contrast, kinetically stable proteins (KSPs) are trapped by an energy barrier in a specific state, unable to transiently sample other conformations. Among many potential roles, it appears that kinetic stability (...

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Autori principali: Xia, Ke, Manning, Marta, Hesham, Helai, Lin, Qishan, Bystroff, Christopher, Colón, Wilfredo
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2077256/
https://ncbi.nlm.nih.gov/pubmed/17956990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705417104
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