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Increased levels of hyper-stable protein aggregates in plasma of older adults

Proteins that misfold into hyper-stable/degradation-resistant species during aging may accumulate and disrupt protein homeostasis (i.e., proteostasis), thereby posing a survival risk to any organism. Using the method diagonal two-dimensional (D2D) SDS-PAGE, which separates hyper-stable SDS-resistant...

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Detalhes bibliográficos
Publicado no:Age (Dordr)
Main Authors: Xia, Ke, Trasatti, Hannah, Wymer, James P., Colón, Wilfredo
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5005920/
https://ncbi.nlm.nih.gov/pubmed/27179971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-016-9919-9
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