Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development

Conservation of the vertebrate body plan has been attributed to the evolutionary stability of gene-regulatory networks (GRNs). We describe a regulatory circuit made up of Gata2, Fli1, and Scl/Tal1 and their enhancers, Gata2-3, Fli1+12, and Scl+19, that operates during specification of hematopoiesis...

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Hlavní autoři: Pimanda, John E., Ottersbach, Katrin, Knezevic, Kathy, Kinston, Sarah, Chan, Wan Y. I., Wilson, Nicola K., Landry, Josette-Renée, Wood, Andrew D., Kolb-Kokocinski, Anja, Green, Anthony R., Tannahill, David, Lacaud, Georges, Kouskoff, Valerie, Göttgens, Berthold
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2077040/
https://ncbi.nlm.nih.gov/pubmed/17962413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707045104
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