Diarylurea Compounds Inhibit Caspase Activation by Preventing the Formation of the Active 700-Kilodalton Apoptosome Complex

The release of mitochondrial proapoptotic proteins into the cytosol is the key event in apoptosis signaling, leading to the activation of caspases. Once in the cytosol, cytochrome c triggers the formation of a caspase-activating protein complex called the apoptosome, whereas Smac/Diablo and Omi/htra...

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Bibliographic Details
Main Authors: Lademann, Ulrik, Cain, Kelvin, Gyrd-Hansen, Mads, Brown, David, Peters, Dan, Jäättelä, Marja
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC207649/
https://ncbi.nlm.nih.gov/pubmed/14560026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.21.7829-7837.2003
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