Histone Deacetylation of RB-Responsive Promoters: Requisite for Specific Gene Repression but Dispensable for Cell Cycle Inhibition

The retinoblastoma tumor suppressor protein (RB) is targeted for inactivation in the majority of human tumors, underscoring its critical role in attenuating cellular proliferation. RB inhibits proliferation by repressing the transcription of genes that are essential for cell cycle progression. To re...

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Detalhes bibliográficos
Main Authors: Siddiqui, Hasan, Solomon, David A., Gunawardena, Ranjaka W., Wang, Ying, Knudsen, Erik S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC207566/
https://ncbi.nlm.nih.gov/pubmed/14560017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.21.7719-7731.2003
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