Two cAMP-dependent pathways differentially regulate exocytosis of large dense-core and small vesicles in mouse β-cells

It has been reported that cAMP regulates Ca(2+)-dependent exocytosis via protein kinase A (PKA) and exchange proteins directly activated by cAMP (Epac) in neurons and secretory cells. It has, however, never been clarified how regulation of Ca(2+)-dependent exocytosis by cAMP differs depending on the...

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Bibliographic Details
Main Authors: Hatakeyama, Hiroyasu, Takahashi, Noriko, Kishimoto, Takuya, Nemoto, Tomomi, Kasai, Haruo
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2007
Subjects:
Cellular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2075257/
https://ncbi.nlm.nih.gov/pubmed/17510178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.135228
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