Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block

We have compared the potencies of structurally distinct channel blockers at recombinant NR1/NR2A, NR1/NR2B, NR1/NR2C and NR1/NR2D receptors. The IC(50) values varied with stereochemistry and subunit composition, suggesting that it may be possible to design subunit-selective channel blockers. For diz...

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Detalhes bibliográficos
Main Authors: Dravid, Shashank M, Erreger, Kevin, Yuan, Hongjie, Nicholson, Katherine, Le, Phuong, Lyuboslavsky, Polina, Almonte, Antoine, Murray, Ernest, Mosely, Cara, Barber, Jeremy, French, Adam, Balster, Robert, Murray, Thomas F, Traynelis, Stephen F
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2007
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2075223/
https://ncbi.nlm.nih.gov/pubmed/17303642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.124958
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