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Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block
We have compared the potencies of structurally distinct channel blockers at recombinant NR1/NR2A, NR1/NR2B, NR1/NR2C and NR1/NR2D receptors. The IC(50) values varied with stereochemistry and subunit composition, suggesting that it may be possible to design subunit-selective channel blockers. For diz...
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| Autori principali: | , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Blackwell Science Inc
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2075223/ https://ncbi.nlm.nih.gov/pubmed/17303642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.124958 |
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