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Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels
Our homology molecular model of the open/inactivated state of the Na(+) channel pore predicts, based on extensive mutagenesis data, that the local anaesthetic lidocaine docks eccentrically below the selectivity filter, such that physical occlusion is incomplete. Electrostatic field calculations sugg...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Blackwell Science Inc
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2075178/ https://ncbi.nlm.nih.gov/pubmed/17363383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.130161 |
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