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Variation in topoisomerase I gene copy number as a mechanism for intrinsic drug sensitivity.

DNA topoisomerase I (topo I) is the principle target for camptothecin and its derivatives such as SN38. Levels of topo I expression vary widely between and within tumour types and the basis for this is poorly understood. We have used fluorescence in situ hybridisation to detect the topo I locus in a...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: McLeod, H. L., Keith, W. N.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 1996
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2074660/
https://ncbi.nlm.nih.gov/pubmed/8761363
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