Modulation of bryostatin 1 muscle toxicity by nifedipine: effects on muscle metabolism and oxygen supply.

Bryostatin 1, an anti-neoplastic agent and protein kinase C activator, has dose-limiting toxicity manifesting as myalgia. Studies in vivo have suggested that this myalgia may be caused by impairment of oxidative metabolism as mitochondrial capacity, muscle reoxygenation and proton washout from muscl...

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Main Authors: Thompson, C. H., Macaulay, V. M., O'Byrne, K. J., Kemp, G. J., Wilner, S. M., Talbot, D. C., Harris, A. L., Radda, G. K.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2074524/
https://ncbi.nlm.nih.gov/pubmed/8630272
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