Modulation of bryostatin 1 muscle toxicity by nifedipine: effects on muscle metabolism and oxygen supply.

Bryostatin 1, an anti-neoplastic agent and protein kinase C activator, has dose-limiting toxicity manifesting as myalgia. Studies in vivo have suggested that this myalgia may be caused by impairment of oxidative metabolism as mitochondrial capacity, muscle reoxygenation and proton washout from muscl...

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Hlavní autoři: Thompson, C. H., Macaulay, V. M., O'Byrne, K. J., Kemp, G. J., Wilner, S. M., Talbot, D. C., Harris, A. L., Radda, G. K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 1996
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2074524/
https://ncbi.nlm.nih.gov/pubmed/8630272
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