Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor.

The results of preclinical and clinical studies indicate enhanced antineoplastic activity of topotecan (SKF 104864-A) when administered as a chronic treatment. We determined the apparent bioavailability and pharmacokinetics of topotecan administered orally to 12 patients with solid tumours in a two-...

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Bibliografske podrobnosti
Main Authors: Schellens, J. H., Creemers, G. J., Beijnen, J. H., Rosing, H., de Boer-Dennert, M., McDonald, M., Davies, B., Verweij, J.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1996
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2074523/
https://ncbi.nlm.nih.gov/pubmed/8630291
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