Cytoplasmic sequestration of an O(6)-methylguanine-DNA methyltransferase enhancer binding protein in DNA repair-deficient human cells

O(6)-Methylguanine-DNA methyltransferase (MGMT), an enzyme that repairs adducts at O(6) of guanine in DNA, is a major determinant of susceptibility to simple methylating carcinogens or of tumor response to anticancer chloroethylating drugs. To investigate the mechanisms underlying cellular expressio...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Chen, Frank Y., Harris, Linda C., Remack, Joanna S., Brent, Thomas P.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20725/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9113992/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.9.4348
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