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Cytoplasmic sequestration of an O(6)-methylguanine-DNA methyltransferase enhancer binding protein in DNA repair-deficient human cells

O(6)-Methylguanine-DNA methyltransferase (MGMT), an enzyme that repairs adducts at O(6) of guanine in DNA, is a major determinant of susceptibility to simple methylating carcinogens or of tumor response to anticancer chloroethylating drugs. To investigate the mechanisms underlying cellular expressio...

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Bibliografiske detaljer
Main Authors: Chen, Frank Y., Harris, Linda C., Remack, Joanna S., Brent, Thomas P.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences of the USA 1997
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC20725/
https://ncbi.nlm.nih.gov/pubmed/9113992
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