In vivo tumorigenesis by Jaagsiekte sheep retrovirus (JSRV) requires Y590 in Env TM, but not full length orfX open reading frame

Jaagsiekte retrovirus (JSRV) causes ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer of sheep. The envelope (Env) glycoprotein protein of JSRV functions as a dominant oncoprotein in vitro and in vivo. An SH2 binding domain (YXXM) in the cytoplasmic tail of the JSRV Env is one of the...

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Hlavní autoři: Cousens, Chris, Maeda, Naoyoshi, Murgia, Claudio, Dagleish, Mark P., Palmarini, Massimo, Fan, Hung
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2065845/
https://ncbi.nlm.nih.gov/pubmed/17610928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2007.06.004
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