Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase

BACKGROUND: The mechanisms involved in the induction and regulation of inflammation resulting in dopaminergic (DA) neurotoxicity in Parkinson's disease (PD) are complex and incompletely understood. Microglia-mediated inflammation has recently been implicated as a critical mechanism responsible...

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Bibliographic Details
Main Authors: Qian, Li, Xu, Zongli, Zhang, Wei, Wilson, Belinda, Hong, Jau-Shyong, Flood, Patrick M
Format: Artigo
Language:Inglês
Published: BioMed Central|1 2007
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064906/
https://ncbi.nlm.nih.gov/pubmed/17880684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-4-23
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