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A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination
In Caenorhabditis elegans, the Gli-family transcription factor TRA-1 is the terminal effector of the sex determination pathway. TRA-1 activity inhibits male development and allows female fates. Genetic studies have indicated that TRA-1 is negatively regulated by the fem-1, fem-2, and fem-3 genes. Ho...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064902/ https://ncbi.nlm.nih.gov/pubmed/17609115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2007.05.008 |
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