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Discovery of novel splice forms and functional analysis of cancer-specific alternative splicing in human expressed sequences
We report here a genome-wide analysis of alternative splicing in 2 million human expressed sequence tags (ESTs), to identify splice forms that are up-regulated in tumors relative to normal tissues. We found strong evidence (P < 0.01) of cancer-specific splice variants in 316 human genes. In total...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2003
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC206480/ https://ncbi.nlm.nih.gov/pubmed/14500827 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg786 |
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