uPA deficiency exacerbates muscular dystrophy in MDX mice

Duchenne muscular dystrophy (DMD) is a fatal and incurable muscle degenerative disorder. We identify a function of the protease urokinase plasminogen activator (uPA) in mdx mice, a mouse model of DMD. The expression of uPA is induced in mdx dystrophic muscle, and the genetic loss of uPA in mdx mice...

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Detalhes bibliográficos
Main Authors: Suelves, Mònica, Vidal, Berta, Serrano, Antonio L., Tjwa, Marc, Roma, Josep, López-Alemany, Roser, Luttun, Aernout, de Lagrán, María Martínez, Díaz, Maria Àngels, Jardí, Mercè, Roig, Manuel, Dierssen, Mara, Dewerchin, Mieke, Carmeliet, Peter, Muñoz-Cánoves, Pura
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064626/
https://ncbi.nlm.nih.gov/pubmed/17785520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200705127
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