Fibrinogen drives dystrophic muscle fibrosis via a TGFβ/alternative macrophage activation pathway

In the fatal degenerative Duchenne muscular dystrophy (DMD), skeletal muscle is progressively replaced by fibrotic tissue. Here, we show that fibrinogen accumulates in dystrophic muscles of DMD patients and mdx mice. Genetic loss or pharmacological depletion of fibrinogen in these mice reduced fibro...

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Detalhes bibliográficos
Main Authors: Vidal, Berta, Serrano, Antonio L., Tjwa, Marc, Suelves, Mònica, Ardite, Esther, De Mori, Roberta, Baeza-Raja, Bernat, Martínez de Lagrán, María, Lafuste, Peggy, Ruiz-Bonilla, Vanessa, Jardí, Mercè, Gherardi, Romain, Christov, Christo, Dierssen, Mara, Carmeliet, Peter, Degen, Jay L., Dewerchin, Mieke, Muñoz-Cánoves, Pura
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492661/
https://ncbi.nlm.nih.gov/pubmed/18593877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.465908
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