Fibrinogen drives dystrophic muscle fibrosis via a TGFβ/alternative macrophage activation pathway

In the fatal degenerative Duchenne muscular dystrophy (DMD), skeletal muscle is progressively replaced by fibrotic tissue. Here, we show that fibrinogen accumulates in dystrophic muscles of DMD patients and mdx mice. Genetic loss or pharmacological depletion of fibrinogen in these mice reduced fibro...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Vidal, Berta, Serrano, Antonio L., Tjwa, Marc, Suelves, Mònica, Ardite, Esther, De Mori, Roberta, Baeza-Raja, Bernat, Martínez de Lagrán, María, Lafuste, Peggy, Ruiz-Bonilla, Vanessa, Jardí, Mercè, Gherardi, Romain, Christov, Christo, Dierssen, Mara, Carmeliet, Peter, Degen, Jay L., Dewerchin, Mieke, Muñoz-Cánoves, Pura
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cold Spring Harbor Laboratory Press 2008
Aiheet:
Research Communication
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492661/
https://ncbi.nlm.nih.gov/pubmed/18593877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.465908
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