Defining early steps in mRNA transport: mutant mRNA in myotonic dystrophy type I is blocked at entry into SC-35 domains

In myotonic dystrophy type 1 (DM1), triplet repeat expansion in the 3′ untranslated region of dystrophia myotonica protein kinase (DMPK) causes the nuclear retention of mutant messenger RNA (mRNA). Although the DMPK gene locus positions precisely at the outer edge of a factor-rich SC-35 domain, the...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Smith, Kelly P., Byron, Meg, Johnson, Carol, Xing, Yigong, Lawrence, Jeanne B.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064620/
https://ncbi.nlm.nih.gov/pubmed/17846170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200706048
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados