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The Mef2 transcription network is disrupted in myotonic dystrophy heart tissue dramatically altering miRNA and mRNA expression
Cardiac dysfunction is the second leading cause of death in myotonic dystrophy type 1 (DM1) primarily due to arrhythmias and cardiac conduction defects. A screen of more than 500 miRNAs in a DM1 mouse model identified 54 that were differentially expressed in heart. More than 80% exhibited down regul...
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| Huvudupphovsmän: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2014
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3927417/ https://ncbi.nlm.nih.gov/pubmed/24412363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.12.025 |
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