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A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage

The molecular role of poly (ADP-ribose) polymerase-1 in DNA repair is unclear. Here, we show that the single-strand break repair protein XRCC1 is rapidly assembled into discrete nuclear foci after oxidative DNA damage at sites of poly (ADP-ribose) synthesis. Poly (ADP-ribose) synthesis peaks during...

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Bibliografiske detaljer
Main Authors: El-Khamisy, Sherif F., Masutani, Mitsuko, Suzuki, Hiroshi, Caldecott, Keith W.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC206461/
https://ncbi.nlm.nih.gov/pubmed/14500814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg761
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