Selective inhibitory DNA aptamers of the human RNase H1

Human RNase H1 binds double-stranded RNA via its N-terminal domain and RNA–DNA hybrid via its C-terminal RNase H domain, the latter being closely related to Escherichia coli RNase HI. Using SELEX, we have generated a set of DNA sequences that can bind efficiently (K(d) values ranging from 10 to 80 n...

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Detalhes bibliográficos
Main Authors: Pileur, Frédéric, Andreola, Marie-Line, Dausse, Eric, Michel, Justine, Moreau, Serge, Yamada, Hirofumi, Gaidamakov, Sergei A., Crouch, Robert J., Toulmé, Jean-Jacques, Cazenave, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC206449/
https://ncbi.nlm.nih.gov/pubmed/14500841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg748
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