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Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells

The idea that conversion of glucose to ATP is an attractive target for cancer therapy has been supported in part by the observation that glucose deprivation induces apoptosis in rodent cells transduced with the proto-oncogene MYC, but not in the parental line. Here, we found that depletion of glucos...

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Autori principali: Yuneva, Mariia, Zamboni, Nicola, Oefner, Peter, Sachidanandam, Ravi, Lazebnik, Yuri
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064426/
https://ncbi.nlm.nih.gov/pubmed/17606868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200703099
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