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DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur
Cleavage of Notch by furin is required to generate a mature, cell surface heterodimeric receptor that can be proteolytically activated to release its intracellular domain, which functions in signal transduction. Current models propose that ligand binding to heterodimeric Notch (hNotch) induces a dis...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2063980/ https://ncbi.nlm.nih.gov/pubmed/17296795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200609014 |
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