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Nebulin-deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle

Nebulin is a giant modular sarcomeric protein that has been proposed to play critical roles in myofibrillogenesis, thin filament length regulation, and muscle contraction. To investigate the functional role of nebulin in vivo, we generated nebulin-deficient mice by using a Cre knock-in strategy. Lin...

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Detalhes bibliográficos
Main Authors: Bang, Marie-Louise, Li, Xiaodong, Littlefield, Ryan, Bremner, Shannon, Thor, Andrea, Knowlton, Kirk U., Lieber, Richard L., Chen, Ju
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063916/
https://ncbi.nlm.nih.gov/pubmed/16769824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200603119
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