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Structural damage to meiotic chromosomes impairs DNA recombination and checkpoint control in mammalian oocytes

Meiosis in human oocytes is a highly error-prone process with profound effects on germ cell and embryo development. The synaptonemal complex protein 3 (SYCP3) transiently supports the structural organization of the meiotic chromosome axis. Offspring derived from murine Sycp3 (−) (/) (−) females die...

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Bibliografiske detaljer
Main Authors: Wang, Hong, Höög, Christer
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063859/
https://ncbi.nlm.nih.gov/pubmed/16717125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200512077
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