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Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility

Rho GTPases participate in various cellular processes, including normal and tumor cell migration. It has been reported that RhoA is targeted for degradation at the leading edge of migrating cells by the E3 ubiquitin ligase Smurf1, and that this is required for the formation of protrusions. We report...

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Detalhes bibliográficos
Main Authors: Sahai, Erik, Garcia-Medina, Raquel, Pouysségur, Jacques, Vial, Emmanuel
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063621/
https://ncbi.nlm.nih.gov/pubmed/17190792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200605135
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