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Regulation of Ci-SCF(Slimb) binding, Ci proteolysis and Hedgehog pathway activity by Ci phosphorylation
Hedgehog (Hh) proteins signal by inhibiting the proteolytic processing of Ci/Gli family transcription factors and by increasing Ci/Gli specific activity. In the absence of Hh, phosphorylation of Ci/Gli triggers binding to SCF ubiquitin ligase complexes and consequent proteolysis. Here we define the...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2063588/ https://ncbi.nlm.nih.gov/pubmed/17925225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2007.09.006 |
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