Identification of amino acid substitutions that alter the substrate specificity of TEM-1 beta-lactamase.
TEM-1 beta-lactamase is the most prevalent plasmid-mediated beta-lactamase in gram-negative bacteria. Recently, TEM beta-lactamase variants with amino acid substitutions in the active-site pocket of the enzyme have been identified in natural isolates with increased resistance to extended-spectrum ce...
Enregistré dans:
| Publié dans: | J Bacteriol |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology (ASM)
1992
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC206357/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1644749/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.174.16.5237-5243.1992 |
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