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Selection of Naturally Occurring Extended-Spectrum TEM β-Lactamase Variants by Fluctuating β-Lactam Pressure

Despite the large number of in vitro mutations that increase resistance to extended-spectrum cephalosporins in TEM-type β-lactamases, only a small number occur in naturally occurring enzymes. In nature, and particularly in the hospital, bacteria that contain β-lactamases encounter simultaneous or co...

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Bibliografische gegevens
Hoofdauteurs: Blazquez, Jesús, Morosini, María-Isabel, Negri, María-Cristina, Baquero, Fernando
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2000
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC90035/
https://ncbi.nlm.nih.gov/pubmed/10898697
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