Selection of Naturally Occurring Extended-Spectrum TEM β-Lactamase Variants by Fluctuating β-Lactam Pressure

Despite the large number of in vitro mutations that increase resistance to extended-spectrum cephalosporins in TEM-type β-lactamases, only a small number occur in naturally occurring enzymes. In nature, and particularly in the hospital, bacteria that contain β-lactamases encounter simultaneous or co...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Blazquez, Jesús, Morosini, María-Isabel, Negri, María-Cristina, Baquero, Fernando
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Mechanisms of Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90035/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10898697/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.8.2182-2184.2000
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