Preclinical and Clinical In Vitro In Vivo Correlation of an hGH Dextran Microsphere Formulation

PURPOSE: To investigate the in vitro in vivo correlation of a sustained release formulation for human growth hormone (hGH) based on hydroxyethyl methacrylated dextran (dex-HEMA) microspheres in Pit-1 deficient Snell dwarf mice and in healthy human volunteers. MATERIALS AND METHODS: A hGH-loaded micr...

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Autori principali: Vlugt-Wensink, K. D. F., de Vrueh, R., Gresnigt, M. G., Hoogerbrugge, C. M., van Buul-Offers, S. C., de Leede, L. G. J., Sterkman, L. G. W., Crommelin, D. J. A., Hennink, W. E., Verrijk, R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2007
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063566/
https://ncbi.nlm.nih.gov/pubmed/17929148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-007-9433-y
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