CIB1 is an endogenous inhibitor of agonist-induced integrin αIIbβ3 activation

In response to agonist stimulation, the αIIbβ3 integrin on platelets is converted to an active conformation that binds fibrinogen and mediates platelet aggregation. This process contributes to both normal hemostasis and thrombosis. Activation of αIIbβ3 is believed to occur in part via engagement of...

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Detalhes bibliográficos
Main Authors: Yuan, Weiping, Leisner, Tina M., McFadden, Andrew W., Wang, Zhengyan, Larson, Mark K., Clark, Shantres, Boudignon-Proudhon, Christel, Lam, Stephen C.-T., Parise, Leslie V.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063547/
https://ncbi.nlm.nih.gov/pubmed/16418530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200505131
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