Characterization of calcium- and integrin-binding protein 1 (CIB1) knockout platelets: Potential compensation by CIB family members

Platelet aggregation requires activation of the αIIbβ3 integrin, an event regulated by the integrin cytoplasmic tails. CIB1 binds to the cytoplasmic tail of the integrin αIIb subunit. Previous overexpression and knockdown studies in murine megakaryocytes demonstrated that CIB1 inhibits integrin αIIb...

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Bibliografiset tiedot
Päätekijät: DeNofrio, Jan C., Yuan, Weiping, Temple, Brenda R., Gentry, Holly R., Parise, Leslie V.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771430/
https://ncbi.nlm.nih.gov/pubmed/18989529
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