Signals Emanating From the Membrane Proximal Region Of The Thrombopoietin Receptor (Mpl) Support Hematopoietic Stem Cell Self-Renewal

(1) OBJECTIVES: Studies using thrombopoietin -/- (TPO-/-) or TPO receptor, mpl -/- mice have established a critical role for TPO/mpl signaling in hematopoietic stem cells (HSC) development. In this study, we further dissected mpl signaling in both megakaryopoiesis and HSC function, using mice bearin...

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Bibliographic Details
Main Authors: Tong, Wei, Ibarra, Yessenia M., Lodish, Harvey F.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2062518/
https://ncbi.nlm.nih.gov/pubmed/17637498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2007.05.010
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