Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6'-N-acetyltransferase Ib and IIa proteins.

The aminoglycoside 6'-N-acetyltransferase [AAC(6')-I] and AAC(6')-II enzymes represent a class of bacterial proteins capable of acetylating tobramycin, netilmicin, and 2'-N-ethylnetilmicin. However, an important difference exists in their abilities to modify amikacin and gentamicin. The AAC(6')-I en...

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Pubblicato in:	J Bacteriol
Autori principali:	Rather, P N, Munayyer, H, Mann, P A, Hare, R S, Miller, G H, Shaw, K J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC205986/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1577689/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.174.10.3196-3203.1992
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