Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus

The large docking protein IRS-1 is a major substrate for the insulin receptor and other tyrosine kinases. It plays a key role in eliciting many of insulin’s actions, including binding and activation of phosphatidylinositol (PI) 3-kinase and the subsequent increase in glucose transport. Gene disrupti...

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Bibliografiska uppgifter
Huvudupphovsmän: Rondinone, Cristina M., Wang, Ling-Mei, Lonnroth, Peter, Wesslau, Christian, Pierce, Jacalyn H., Smith, Ulf
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences of the USA 1997
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC20591/
https://ncbi.nlm.nih.gov/pubmed/9108124
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