Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus

The large docking protein IRS-1 is a major substrate for the insulin receptor and other tyrosine kinases. It plays a key role in eliciting many of insulin’s actions, including binding and activation of phosphatidylinositol (PI) 3-kinase and the subsequent increase in glucose transport. Gene disrupti...

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Bibliografische Detailangaben

Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Rondinone, Cristina M., Wang, Ling-Mei, Lonnroth, Peter, Wesslau, Christian, Pierce, Jacalyn H., Smith, Ulf
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1997
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20591/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9108124/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.8.4171
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