Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: relevance in drug design

Destabilization of the tetrameric fold of TTR (transthyretin) is important for aggregation of the protein which culminates in amyloid fibril formation. Many TTR mutations interfere with tetramer stability, increasing the amyloidogenic potential of the protein. The vast majority of proposed TTR fibri...

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Detalhes bibliográficos
Main Authors: Cardoso, Isabel, Almeida, Maria Rosário, Ferreira, Nelson, Arsequell, Gemma, Valencia, Gregorio, Saraiva, Maria João
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2049069/
https://ncbi.nlm.nih.gov/pubmed/17683281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070689
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