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Design of TATA box-binding protein/zinc finger fusions for targeted regulation of gene expression

Fusing the TATA box-binding protein (TBP) to other DNA-binding domains may provide a powerful way of targeting TBP to particular promoters. To explore this possibility, a structure-based design strategy was used to construct a fusion protein, TBP/ZF, in which the three zinc fingers of Zif268 were li...

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Bibliografske podrobnosti
Main Authors: Kim, Jin-Soo, Kim, Jaesang, Cepek, Karyn L., Sharp, Phillip A., Pabo, Carl O.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences of the USA 1997
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC20489/
https://ncbi.nlm.nih.gov/pubmed/9108026
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